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HPV and Cervical Cancer
Cervical CancerWhile HPV infection is the leading cause of cervical cancer, in reality it is very rare for HPV infection to progress to cancer with proper treatment. 60 to 80 % of CIN 1 dysplasias resolve on their own, and only about 1% of cases progress to invasive cervical cancer.
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HPV CLEARANCE Are You dealing with the complex emotions of dating with HPV? We're here to give you the facts and some advice get your dating life back on track!
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How Common is HPV?
HPV STATISTICSStudies suggest as many as 80% of people will aquire genital HPV. Several estimates have placed the lifetime likelihood of exposure to HPV in the range of 75-90% though most will not show symptoms.
Sources

HPV VACCINE NEWS

Sources: Wikipedia, The Free Encyclopedia


Latest HPV Vaccine News
On June 8, 2006, the FDA approved Gardasil, a prophylactic HPV vaccine which is marketed by Merck. The vaccine protects women against initial infection with HPV types 16 and 18, which together cause 70 percent of cervical cancers. The vaccine also protects against HPV types 6 and 11, which cause 90 percent of genital warts. Women aged nine through twenty-six can be vaccinated. GlaxoSmithKline is expected to seek approval for a prophylactic vaccine targeting HPV types 16 and 18 early in 2007. Since the vaccine will not protect women against all the HPV types that cause cervical cancer, it will be important for women to continue to seek Pap smear testing, even after receiving the vaccine.

As of April, 2005, Merck & Co. was in the final stages of a Phase III human trial (including over 25 000 women) for a HPV vaccine which targets types 16 and 18 and types 6 and 11 of the virus, which cause cervical cancer and visible genital warts respectively. They expect this trial to conclude by the end of 2005, and hope to apply to the United States Food and Drug Administration for permission to release it commercially. GlaxoSmithKline is also working on a vaccine which only targets the cancer-causing types 16 and 18. GSK's vaccine is also in the midst of a Phase III human trial (over 30 000 women), but that study commenced in 2004 and is still running.

UPDATE! In October 2005 Merck & Co Announced that Gardasil, (the brand name under which the vaccine is to be marketed) was found 100% effective at blocking HPV 16 and 18. These two strains of the HPV virus are responsible for 70% of cervical cancers.


When Will The HPV Vaccine Be Available?
Currently, in Great Britain a vaccination study is under way. It is targeting the four virus strains that are most often responsible for cervical cancer and for abnormal smear test results. In prior trials, Merck and Co.'s Gardasil vaccine reduced HPV infections by about 90% and pre-cancerous cells were totally eliminated. It is hoped that the vaccine can be released for medical use in two years.

UPDATE! Merck plans by the end of 2005 to seek Food and Drug Administration approval to sell its vaccine for use by girls and young women. If all goes well the vaccine should be on the market sometime in 2006.


What does the HPV Vaccine do?
The HPV Vaccines are being studied for their preventative and therapeutic benefits against HPV infection. A Phase III trial of the vaccine presented in May found that all participants experienced 100% antibody responses to the HPV strains 6, 11 and 16, 99.9% of boys and girls ages 10 to 15 developed antibody responses to HPV strain 18, and 99.1% of 16- to 23-year-old women developed strain 18 antibodies. Strains 6, 11, 16 and 18 of HPV are the most likely to cause cervical cancer or genital warts ( Kaisernetwork.org). In terms of cancer prevention, the vaccines currently being researched only target virus types 16 and 18, which account for about 70% of cancer cases. Adding other virus types increases cost, complexity and development time, with approximately 13 other virus types required to achieve 100% coverage of cancer-causing strains. Virus types 6 and 11, which Merck's vaccine targets, are not responsible for cervical cancer, but rather for visible warts. This is expected to help market the vaccine to men, who may otherwise have no interest in taking a drug which doesn't benefit them directly.


What further research is being done on the HPV Vaccine?
Research is focusing on the prevention of cervical cancer, particularly in developing countries, where regular cervical examinations, including Pap smears, are uncommon. 270 000 women died of cervical cancer worldwide in 2002. Only 5000 of those deaths occurred in the United States. This is credited to the prevalence of regular exams, including Pap smear tests, in the US. Thankfully, the vaccines being studied have proven very effective (100% in some studies) at stopping HPV, with few or no side effects. Researchers are very optimistic that these vaccines will be available for distribution soon.


Is HPV Vaccination foolproof?
One unknown aspect of the vaccines now being researched is their longevity. Since the studies have only been run for relatively small periods of time, it's unknown whether the vaccines will last just a few years (as few as three) or for much longer. Further study over time is required to answer this question.



HPV Forum Articles
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  • HPV and Dating - tips and advice on getting out and dating again after HPV diagnosis. Find someone new today!
  • HPV Video Content - Watch videos from experts in the field of HPV and cervical cancer
  • Pictures of Genital Warts - view images of genital warts from around the web taken by clinicians
  • HPV Questions and Answers - Is there a cure for HPV? Will HPV cause cancer? Find Answers about HPV and ask questions.
  • HPV Vaccine - what it does, when to expect it, and clinical trials being done on an HPV Vaccine from Merck & Co.
  • Cervical Dysplasia - what you need to know about Cervical Dysplasia and its role in cervical cancer development
  • HPV Clearance - According to studies up to 90% of those infected with HPV clear the virus from their body within 8-24 months.
  • How To Tell Your Partner About HPV Cervical Changes - a guide to telling your partner about abnormal pap smear results
  • How To Tell Your Partner About Genital Warts - a guide to telling your partner about genital warts diagnosis
  • How To Tell A New Partner About HPV - learn the facts about HPV first, then use this script
  • Why Tell A New Partner About HPV - with HPV being so common, and often times transient why do you need to disclose?
  • HPV and Condoms: The Great Debate - should we teach abstinence only education? Is HPV infection deadly?
  • HPV Primer - Information about HPV, Genital Warts, Pap Smears and more for those who need to know
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